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313,314 In one study, OA was induced in rats by injecting MIA into the knee joint, mimicking the pathological changes of human OA

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Chronic hypoxia promotes ceramide hydrolytic metabolism by activating the HIF-2/Acer2 signaling pathway, and thereby downregulates PP2A activity The above study found that hypoxia caused -syn hyperphosphorylation by inhibiting PP2A activity