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Shorter needles (e.g., 5mm or 6mm) are insufficient for reliable subcutaneous injection, while longer needles (10mm or more) risk penetrating intramuscular or neurovascular structures

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Adequate hydration is particularly important for people taking retatrutide, as nausea and vomiting the most commonly reported gastrointestinal side effects in clinical trials can lead to fluid and electrolyte losses

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The net effect is stored triglycerides getting broken apart into free fatty acids and glycerol, which the body can then burn for energy