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The breadth of gene modulation raises a fundamental question: how does a three-amino-acid peptide influence thousands of genes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Ioannou G.N., Gowda G.A.N., Djukovic D., Raftery D

Studies have postulated that the cause may be ascribed to the reduction in the excitability of pain transmitting dorsal horn neurons via hyperpolarization due to MT1/2-melatonin binding 89