Initially EpRE was called the antioxidant response element (ARE) because the first compound, shown to activate ARE was a so-called antioxidant that was subsequently shown to generate H 2 O 2 through redox cycling (Pinkus et al., 1996)
Observational studies have indicated that low selenium status is an iodine-independent risk factor for goitre
While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis (Esteller, 2008
doi: 10.1152/ajplung.1998.275.5.L861
To fully enjoy the benefits of glutathione, its best to eat fresh fruits (camu camu, acerola...) and lightly cooked vegetables , ideally not overprocessed , to prevent glutathione degradation
9 BrzywczyJ.PaszewskiA