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increased proximally to the middle of the esophagus and then decreased significantly in the distal esophagus, with gram-negative(G-) microorganisms concentrated in the distal esophagus ( 2.2.1 Changes in esophageal microbiome by age, medicine, and diet which potentially affecting GERD Esophageal microbiome changes with age

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Each parameter was evaluated using a semi-quantitative scale: absent (0), mild (14), moderate (56), severe (78), and very severe (910)

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Mast cells are essential for regulating inflammatory responses, which are considered vital during the early stages of wound healing