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Retrieved from (Provides insight into niacins safety profile: nicotinic acid commonly causes flushing at doses 30 mg

The newly formed vessels within the tumor have an immature phenotype characterized by limited contact between endothelial cells and defective or discontinuous basement membrane

In some embodiments, the otoprotectant is a compound of Formula (V) having the structure of Formula (Va): In some embodiments, the otoprotectant is a compound of Formula (VI): wherein: X is a pharmaceutically acceptable counterion