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KPV works on NF-kB itself

ACS Chem Neurosci 12:33353346 Hofmann C, Pizzagalli F, Boetsch C, Alberati D, Ereshefsky L, Jhee S, Patat A, Boutouyrie-Dumont B, Martin-Facklam M (2016) Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers

10.1128/IAI.05913-11 Infect

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What This Means for Experimental Design IGFBP Interactions: Degree of Reduction Differs Both analogs reduce IGFBP binding, but not equally: IGF-1 LR3 achieves approximately 1,000-fold reduction in affinity for all major IGFBPs

Clin Chem Lab Med (CCLM)