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Adipocyte & Metabolic Research: Frequently used in laboratory models studying lipid storage, energy expenditure, and metabolic adaptation

Elevated insulin blocks fat mobilization, rendering the peptide less effective

61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent

However, the current research suggests that the dose found to do so may still be insufficient to keep vitamin B12 levels optimal

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