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(PubMed) O'Callaghan B, Bosch AM, Houlden H

doi: 10.1179/1351000215Y.0000000004

Review of clinical trials evaluating safety and efficacy of milk thistle ( Silybum marianum [L.] Gaertn.)

This, in turn, may result in decreased infiltration of inflammatory cells into lung tissues in murine models, alongside lower levels of tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) production, further mitigating tissue damage

It also shifts melanin production from the darker eumelanin toward the lighter pheomelanin, which is why it is used for skin brightening

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