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[10] [11] Intranasal delivery is favored partly because it exploits nose-to-brain transport pathways that may allow a fraction of the peptide to reach the central nervous system while bypassing some first-pass degradation, and pharmacokinetic work in rats has specifically characterized Semax penetration into brain and blood after intranasal administration

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References Kolomin, T., Shadrina, M., Slominsky, P., Limborska, S., & Myasoedov, N

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