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2009;297:C253C62

Clinical trials in patients with metabolic syndrome reveal that L-Carnitine supplementation of 2 g/day for extended periods (25-50 weeks) significantly reduces fasting blood glucose, HbA1c, homeostatic model assessment-insulin resistance (HOMA-IR), inflammatory markers including C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-), and triglyceride levels

For example, in arterial hypertension, increased reactive oxygen species (ROS) and pro-inflammatory cytokines are regulated by histone deacetylase (HDAC) enzymes, which modulate the gene expression of these hypertension-promoting factors

Pericytes Pericytes are vascular mural cells that grow in close proximity to the brain endothelial cells, embedded in the basement membrane, covering ~90% of the capillary bed [26]

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