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Vitamin C is, therefore, required for the maintenance of normal connective tissue as well as for wound healing since synthesis of connective tissue is the first event in wound tissue remodeling

Risk is elevated in patients with a history of abdominal surgery, chronic acid-suppressing medication use, hypothyroidism, diabetes, immune deficiency, or connective tissue disorders

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Notably, the protective effects of irisin were abated by the administration of the SIRT1 inhibitor EX527 in vivo or by siRNA-mediated knockdown of SIRT1 in vitro