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Furthermore, the expression of Bax in ovarian tissue was suppressed, while the expressions of SIRT1, PGC1, NRF1, COX IV, FSH receptors (FSHR), CYP19A1, PI3K, Bcl-2, and p-Akt/Akt were enhanced [39]

Corren, J

Absence of large-scale clinical trials, delaying regulatory approvals and mainstream adoption (McGleenon et al., 1999)

In addition, oxygen-evoked regulation of HIF-1 and NF-B is closely coupled with the intracellular redox state, such that modulating redox equilibrium affects their responsiveness at the molecular level (expression/transactivation)

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"FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation." Communications Biology