first reported the dedifferentiation of hepatocytes into fibroblasts via EMT ( Snail and Slug , repressing the mesenchymal program and EMT of hepatocytes ( Hepatocytes could also dedifferentiate into hepatic progenitor cells (HPCs, which are identified by markers such as SMA, SOX9, KRT19, EpCAM, and PROM1), and the proliferation and differentiation of hepatocyte-derived HPCs are closely associated with ductular reactions and portal fibrosis in liver injury ( Mat1a - / - mice transformed into fibroblastic cells when incubated with FGF10 and TGF-1, and these HPC-derived fibroblasts were significantly expanded in RRV-induced BA mouse model ( 9
Kim and Egan (2008)
Moreover, the elevated GSH levels in intestinal tissues observed following metformin treatment may originate from the gut microbiota, as indicated by the upregulation of the GshF gene
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Despite their promising therapeutic value, the efficacy of PCs can be compromised by their environmental instability and low bioavailability
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