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They release their own inflammatory signals, including chemokines that recruit even more immune cells to the area

In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis

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[DOI] [PubMed] [Google Scholar] 62.Lake AC, Sun Y, Li JL, Kim JE, Johnson JW, et al

Curiously, Agm negatively correlated with NOS activity only in prefrontal cortex, suggesting an aging interaction between these systems only where Agm is depleted (Gupta et al., 2012)