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Standard Research Protocol Dose: 500 mcg (1 capsule) Duration: 4 6 weeks Frequency: 1 capsule once daily with water Cycle Interval: 2 4 weeks off before repeating Goal / Description: Baseline oral dosing investigated for gastrointestinal and connective tissue recovery models

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Inducible suppression of NRF2 (tet_NRF2 KD ) decreased the expression of SLC7A11 but not of LDHB, as did LDHB KD, which reduced SLC7A11 but barely affected NRF2 expression ( Figure 6g )

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