Juriah KAMALUDEEN3 1 Department of Health Studies, Faculty of Vocational Studies, Airlangga University, Jalan Dharmawangsa Dalam 28-30, 60286 Surabaya, Indonesia 2 Department of Veterinary Clinic, Faculty of Veterinary Medicine, Airlangga University, Jalan Mulyorejo 60115 Surabaya, Indonesia 3 Department of Animal Science and Fishery, Faculty of Agriculture and Forestry, University Putra Malaysia, Bintulu Sarawak Campus, 97008 Bintulu, Sarawak, Malaysia Abstract N -acetylcysteine (NAC), a derivative of the amino acid cysteine, is widely recognised for its diverse pharmacological properties, including antioxidant, anti-inflammatory, and mucolytic effects
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Similarly, authors [3] of the first double-blind, randomized, placebo-controlled clinical trial of oral glutathione (GSH) supplementation performed in healthy adult humans concluded that despite the biochemical plausibility, optimal dose, recommended timing of administration and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione (GSH) concentrations following 4 weeks of oral (2 x 500mg daily) glutathione (GSH) supplementation
When interpreting the tests results, it is important to keep in mind that both lactulose and mannitol are metabolized by the colonic microbiota, thus cannot be used in ulcerative colitis or irritable bowel syndrome, which mostly affect the colon
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