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Tirzepatide combines GIP receptor agonism with GLP-1 agonism in a single molecule
The advantage of this type of compounds, apart from the reduction in side effects, is their efficient metabolism to non-toxic products and a high affinity for specific molecular targets, which can potentially be associated with enhanced treatment efficacy, enabling the use of a relatively low dose to produce identical biological effects [3]
10.1161/STROKEAHA.115.011932 [DOI] [PMC free article] [PubMed] [Google Scholar] Hossain, M
Effects of atomoxetine for cognitive function in methamphetamine-dependent patients: a randomized controlled trial
The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 67% discontinued treatment due to AE, 3444% experienced nausea, 2132% diarrhoea and 2225% vomiting) [11, 29]
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