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Research has focused on the role of nutritional antioxidants because of evidence that light-induced oxidative damage of lens proteins may lead to the development of age-related cataracts

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The increase in IGFBP-1 and -2 leads to secondary increases in circulating IGF-I binding capacity that results in high total IGF-I, but decreased IGF-I bioactivity (77, 78) ( Figure 4 )

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10.1523/JNEUROSCI.0984-06.2006 96 KhaibullinT.IvanovaV.MartynovaE.CherepnevG.KhabirovF.GranatovE.et al (2017)