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Together, these features explain how apparently similar pathway blocks can generate receptor- and context-specific effects, including for InsRec [152,153,154,155,156,157,158,159,160,161,162,163]

Retreatment with ICI after a clinically significant previous irAE is common

Some studies point to the ability of serine, a nonessential amino acid, to boost glutathione production, potentially through increased cysteine availability and a decrease of hypermethylation

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This enzyme is inhibited by oxidation (Hancock et al., 2006), and has been identified as a glutathionylated protein (Dixon et al., 2005

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