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One proposed mechanism is that lactate enhances hippocampal neuronal firing, potentially contributing to panic symptoms ( Holdemanella has been associated with reduced right amygdala and hippocampal volumes (Wanapaisan et al., 2022) brain regions consistently reduced in PTSD individuals ( Additional population studies have expanded these findings

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According to the NIH, common doses range from 3 milligrams (mg) to 5,000 mg daily, with an average 14% to 18% uptake rate

Acknowledgements We are grateful to Jens Brning for providing the IR flox/flox mice

Nat Struct Mol Biol (2025)