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Elevated plasma caffeine and its metabolite levels indicate reduced hepatic CYP1A2 activity, and fecal 6-hydroxytestosterone (metabolized by CYP3A4) levels are lower

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We estimated physiological NADP + and NADPH levels in our healthy cohorts, based on frozen sample results, and validated the theoretical calculation by analyzing fresh whole blood samples from 12 additional healthy volunteers (Supplementary Table 5)

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