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Following near-total ablation of -cells in mice, -cells can transform into bihormonal (insulin + /glucagon + ) cells and subsequently into monohormonal insulin + cells (Thorel et al., 2010)
Increased cystine uptake, via the increased expression of the SCL7A11 transporter, has been shown to contribute to changes in the epigenome
Histological changes, transforming growth factor- (TGF-) immuno-expression were also evaluated
Angiogenesis Studied for its role in new blood-vessel formation via VEGF and nitric-oxide signalling pathways
423 The study began by inducing inflammation in mice through the injection of various Toll-like receptor (TLR) agonists and then assessed the inflammation by measuring plasma tumor necrosis factor-alpha (TNF-) levels