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(2019) performed a randomized controlled trial involving 56 women with PCOS, revealing a decrease in hirsutism, total testosterone, hs-CRP, and MDA, alongside an increase in TAC and total GSH among participants administered 5 g of melatonin twice daily for 12 weeks, in contrast to the placebo group [186]

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After 4 weeks of D-galactose injections, the D-Gal group mice received intraperitoneal injections of PBS every 2 days for 4 weeks, followed by tissue collection