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The -syn levels in the hippocampi of heterozygous -syn knockout mice were significantly lower than in wild-type mice (Fig

Lee BM, Rodriguez A, Mena G, Gottumukkala V, Mehran RJ, Rice DC , Feng L, Yu J, Cata JP

But thats not the only role it plays

The current model suggests that de novo myelination is regulated by a combination of pro-myelinating cues and the removal or absence of inhibitory cues (Redmond et al., 2016)