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For example, copper ions can lead to GSH depletion through two mechanisms: the direct downregulation via the redox reaction between Cu 2+ and intracellular GSH, and the activation of a Fenton-like reaction by generating Cu + to amplify oxidative stress (Dong et al., 2020)

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However, the stabilization of HIF-1 remains the major mechanism by which SCFAs act [111]

S S Korsakova 122 , 514 (2022)