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The progressive ramp through the cycle is intentional: it allows the body to respond to the compound gradually, lets the provider assess tolerance and response before increasing the dose, and avoids the unnecessary load of starting at maximum dosing when the tissue is still in early repair phases

The use of RIPK1 inhibitor (Necrostatin-1) [238] combined with NAC can block oxidative stress by reducing H 2 O 2 /O/OH/LOOH, therefore significantly decreasing myocardial cell damage and improving cardiac function [239]

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