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de Gramont A, Van Cutsem E, Schmoll HJ, Tabernero J, Clarke S, Moore MJ, et al

Yes unopened bacteriostatic water vials are shelf-stable at controlled room temperature (2025C) for the full manufacturer expiration period, typically 2436 months

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Estriol is the weakest binding primary estrogen at the estrogen receptors and can compete with stronger-binding estrogens