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Golding points out that unless the enterohepatic circulation is disrupted, holotranscobalamin levels wont significantly decrease until the livers B12 stores are depleted (Golding, 2016)

Weight gain is caused by a combination of factors

Lipotropic injection Lipotropic injections are a combination of B vitamins and amino acids, typically methionine, inositol, and choline, that work together to support liver function and enhance fat metabolism

You do not have to wait until something feels wrong to feel better

They may be useful for those with gastrointestinal issues, older adults, vegans, and vegetarians

(PubMed) Spence JD, Yi Q, Hankey GJ