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Considering this enforced lipogenesis, an argument against -oxidation in solid tumors is substantiated by the reductive stress of the cancer cell interior

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This study, which appears to be unique to the literature in that it systematically assessed time-of-day effects on antioxidant efficacy, is suggestive of a time-of-day-dependent antioxidant response relevant to sleep and sleepiness (Figure 9B)

For instance, IGF-1 overexpression leads to brain overgrowth by increasing the number of neurons and oligodendrocytes, while loss-of-function mutations in IGF-1 or IGF1Rs result in brain growth retardation (28) (Figure 2)

doi: 10.1021/jf0728146