Acetylcarnitine, on the other hand, affects the epigenetic regulation of metabotropic glutamate type 2 receptors (mGluR2), negatively modulating neurotransmitter release and producing rapid and long-lasting antidepressant effects (demonstrated by forced swim tests, sucrose preference tests) in Flinders Sensitive Line rats and in mice exposed to chronic unpredictable stress, which model genetic and environmentally induced depression, respectively [92]
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Anecdotal reports suggest that all three peptides appear synergistic when combined as a blend, potentially providing unique peptide action
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Beaudin AE, Stover PJ
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