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Despite their good properties and high drug-coupling capacity poly(l-glutamic acid) nanosystems have been rarely investigated for brain drug delivery [23, 24]

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cerevisiae , three different components of the UPS, the Ub-conjugase Rad6, the Ub-ligase Bre1, and the deubiquitinase Ubp2, were shown to work in concert to regulate K63-linked polyubiquitination of various ribosomal proteins (Silva et al., 2015)