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The G value of + 13.0 kcal/mol for p.Arg106Pro most probably underestimates the effect of the variant because the WT model has the residues 110-112 and 108-112 missing in chains A and B, respectively, and the residues around the variant, including Arg106, have high B-factors, i.e., the position of the side chain does not have high accuracy due, for example, to dynamics
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Mitochondrial Dysregulation and Oxidative Stress in Patients with Chronic Kidney Disease