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Superoxide dismutase is the body's first line of enzymatic defense against intracellular free radical production through reduction of one-electron dismutation of oxygen (O 2 - ) to hydrogen peroxide (H 2 O 2 ) [10]

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ROS generation leads to oxidation of the ASK1 inhibitor thioredoxin, separating and activating ASK1 from the inactive ASK1thioredoxin complex

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The Mechanisms Explained Understanding the mechanism is key to understanding why the results are so broad