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Safety of Cagrinlitide and CagriSema In the obesity trial, the proportions of participants who discontinued study treatment due to adverse events were 2-6Percentage, 7Percentage, and 3Percentage in the cagrilintide, liraglutide and placebo groups, respectively [9]

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The weight loss effect depends specifically on AMY1R and AMY3R activation, as confirmed by a study in eBioMedicine that showed cagrilintide lowers body weight through these specific receptor subtypes in the brainstem