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442,443,444 Metformin is a biguanide antidiabetic medication that was initially approved by the FDA in 1995 for the treatment of type 2 diabetes

The enzyme glutathione reductase (GR) uses electrons derived from the pentose phosphate pathway to reduce GSSG back into two functional, active GSH molecules, restoring the cellular defense system

Results Hessian fly induces higher levels of glutathione in resistant plants The levels of total glutathione (GSH+GSSG) increased steadily in tissues at the feeding site in resistant plants after Hessian fly infestation (Figure 1)

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Extended Data Fig

Glutathione efficacy soars for immune support (400% NK cell boost) and more