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Funding This research was supported by an Operating Grant (MOP142230) from the Canadian Institutes of Health Research (WGF), and salary support was provided by the Canadian Institutes of Health Research Fellowship Award (MFE-381806) (JMW)

Pivaloyl-forming drugs can deplete carnitine stores and warrant attention when used long term

Timing considerations AOD 9604 works best when injected in a fasted state

Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling

Athletes undergoing high-volume training may experience immune support, though performance enhancement findings are mixed

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