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A double-blind, placebo-controlled trial in frail elderly people without cognitive impairment found significant improvements in cognition from baseline with NAC, 1800 mg per day for 6 weeks, whilst there were no improvements in the placebo group

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Nature Communications 2024;15(1)

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Aging Cell 6:165177 McCarty MF, Barroso-Aranda J, Contreras F (2009) The rejuvenatory impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha