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SLC7A11, a key FRG in pan-RCC and a major functional subunit of the system X c , which participates in cysteine transport and inhibits cellular ferroptosis by participating in GSH synthesis, seems to have opposite effects on the regulation of disulfidptosis and ferroptosis, and further exploration of both of these effects is needed (185)

While berberine is not an insulin secretagogue, its AMPK-mediated glucose lowering produces a functionally analogous additive risk in combination with incretin therapy