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Glutathione is also a constituent in the regulation of protein and gene expression, exchange reactions including thiol to disulfide ratios involve glutathione.4 Glutathione can exist intracellularly in either an oxidized (glutathione disulfide) or reduced (glutathione) molecular state

Sixteen of these cell lines were sensitive to CB-839 treatment and had an antiproliferative IC 50 of less than 100 nM (range, 2-72 nM)

Conversely, Revuelta et al

& Manley, J

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