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A long half-life of roughly 6 days makes a single weekly subcutaneous injection practical, while gradual titration keeps tolerability high from the first dose [1] [4]
Furthermore, the label of chemically identical is often misleading, says Nitai Gelber, a Toronto-based sports medicine physician
Hydroxypropyl-beta-cyclodextrins (CAS: 128446-35-5/94035-02-6) are commercially available for use as excipients, with average molar substitutions (MS) including: MS 0.62, with a molar substitution range of 0.58-0.68
The NIDDK would like to thank: Michael Camilleri, M.D., Mayo Clinic, Rochester
During that period, the stomach eventually loses its ability to absorb vitamin B12 and other nutrients
Reconstitution requires bacteriostatic water (water containing 0.9% benzyl alcohol as a preservative): Standard Reconstitution: Add 2 mL of bacteriostatic water to a 5 mg vial, creating a concentration of 2.5 mg/mL (2,500 mcg/mL)
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