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The global societal burden is equally significant, with total direct and indirect costs estimated to exceed $112 billion USD annually by 2023 (Ola et al., 2022

10.1007/978-1-0716-2099-1_12 125 OeiS

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They arent illegal or banned, but they could cause problems like a damaged liver or gut lining

It protected the gut lining from corrosive agents like NSAIDs (non-steroidal anti-inflammatory drugs) that normally cause bleeding and ulcers

Perhaps most importantly, individuals with malabsorption issues may take oral supplements faithfully yet remain deficient, wasting money and time while symptoms persist