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High-dose oral B12 can still be effective for those with mild absorption problems

Work from David Savages group showed that PLIN1 mutations from patients with lipodystrophies, which lack the C-terminus, fail to stabilize ABHD5 on LDs, resulting in greater basal lipolysis (137) and likely explains why these patients are unable to sequester FAs into TAGs

Its used to treat deficiencies in both vitamins at once

Intramuscular (IM) injections bypass the gastrointestinal tract entirely, making them particularly effective when oral absorption is unreliable or when a confirmed deficiency requires prompt correction

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improving mental clarity and focus, and reducing stress and anxiety