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10.1038/s41418-024-01286-6 195 SongX.ZhuS.ChenP.HouW.WenQ.LiuJ.et al (2018)
Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N -hexanoic-Tyr-Ile-(6) aminohexanoic amide (dihexa), a potent cognitive-enhancing molecule that proved to be very stable, capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, slowly cleared from the blood compartment, and sufficiently BBB-permeable
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Sensorgrams were analyzed using a global fit to the 1:1 Langmuir binding model
