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-KG acts as a cofactor for epigenetic enzymes such as TET dioxygenases and Jumonji histone demethylases, directly influencing the DNA methylation status of the Foxp3 locus (112)

Frequent loss of heterozygosity (LOH) on chromosome 3p in lung tumors was associated with low GPx1 enzyme activities, which may affect the prognosis of lung cancer patients [86]

It has been demonstrated that oxidative stress-mediated GSH depletion is crucial in controlling transient outward K+ currents in rat ventricular myocytes, which may be the cause of diabetes-related decreased contractility and aberrant electrical characteristics

Although we found an optimized sequence for the FOXO4 FHD-p53 TAD interaction, it did not show senolytic activity by itself (Figure

(PubMed) Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu L

A deficiency can erode this coating and cause neuropathy (tingling, numbness, or pain in the hands and feet)