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However, excessive ROS accumulation can lead to oxidative damage, disrupting cellular components and ultimately triggering cell death [4]

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Exploratory pharmacodynamic endpoints included changes in bodyweight, glycemic parameters, and hormones

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When a spinal segment is immobilized, there is increased load on the adjacent levels disc and facet joint which in turn cause abnormal motion and hence a resultant compensatory arthritis formation response which leads to lumbar stenosis (Fig 2)