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These properties have led to the hypothesis of its efficacy for the treatment of melasma
M.Abdel-WahhabK
While direct evidence in human tinnitus tissue is scarce and no study has yet demonstrated HDAC isoform alterations specifically in the AC in tinnitus models, pharmacological inhibition of HDAC3 in the AC has been shown to accelerate learning and strengthen cortical encoding of behaviorally relevant sounds, demonstrating that HDAC-mediated mechanisms can directly regulate AC plasticity (Ateyakar and Bieszczad, 2026)
Glutathione peroxidase catalyzes reactions in which the enzyme reduces hydrogen peroxide to water, as well as organic hydroperoxides (ROOH) to hydroxy derivatives, resulting in the conversion to the oxidized disulfide form GS-SG: H2O2 + 2GSH = GS-SG + H2O ROOH + 2GSH = GS-SG + ROH +H2O Glutathione peroxidase neutralizes peroxynitrite: ONOO- + 2GSH N2- + GSSG + 22 Glutathione reductase is a flavoprotein with a flavin adenine dinucleotide prosthetic group and consists of two identical subunits
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