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A High-Performance Liquid Chromatography (HPLC) validation method was developed for both CA and CF for the first time in this study to detect the concentration of CF and CA in the permeation samples

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HSYA, known for its excellent blood-brain barrier permeability, improves depressive behavior by inhibiting hippocampal inflammation and oxidative stress (Liu Z

D., Nichols, J

Cell Host Microbe 20:202214

The likely reason for this observation is a different preference of astrocytes and neurons to use extracellular amino acids as precursors for the intracellular substrates needed for GSH synthesis