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The discontinuation rate in clinical trials ranged between 20% and 50% within the first year, with GI intolerance being the primary reason

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In: Goodman & Gilman's Pharmacological Basis for Therapeutics

The resulting polypeptides were then eluted and precipitated with salt which provided a new, intermediate starting material that was then separated with chromatography (Jrnvall, Agerberth, Zasloff)