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For Wegovy, the escalation occurs over 16-20 weeks to reach the 2.4 mg maintenance dose

However, PPAR was downregulated in patients with NASH compared to patients with steatosis and healthy controls [75, 86], and the expression of PPAR decreased with increasing NAFLD activity score and fibrosis stage [86]

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However, reassuringly, in the obesity phase 2 trial, self-reported physical function improved with all doses of retatrutide [45]

doi: 10.1007/s40520-024-02853-0 10 LanXLiLJiaQHeFKuangGZengWet al